3,5-Dichlorophenylmagnesium bromide, 0.50 M in THF
bromo(3,5-dichlorophenyl)magnesium
CAS: 82297-90-3
Molecular Formula: C6H3BrCl2Mg
3,5-Dichlorophenylmagnesium bromide, 0.50 M in THF - Names and Identifiers
| Name | bromo(3,5-dichlorophenyl)magnesium |
| Synonyms | bromo(3,5-dichlorophenyl)magnesium magnesium,1,3-dichlorobenzene-5-ide,bromide 3,5-Dichlorophenylmagnesium bromide, 0.50 M in THF 3,5-DichlorophenylMagnesiuM broMide, 0.50M in 2-MeTHF 3,5-Dichlorophenylmagnesium bromide solution 0.5 in THF 3,5-Dichlorophenylmagnesium bromide solution 0.5 M in THF 3,5-Dichlorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal 3,5-DichlorophenylMagnesiuM broMide, 0.50 M solution in 2-Methyltetrahydrofuran |
| CAS | 82297-90-3 |
| InChI | InChI=1/C6H3Cl2.BrH.Mg/c7-5-2-1-3-6(8)4-5;;/h2-4H;1H;/q;;+1/p-1/rC6H3BrCl2Mg/c7-10-6-2-4(8)1-5(9)3-6/h1-3H |
3,5-Dichlorophenylmagnesium bromide, 0.50 M in THF - Physico-chemical Properties
| Molecular Formula | C6H3BrCl2Mg |
| Molar Mass | 250.2 |
| Density | 0.972g/mLat 25°C |
| Boling Point | 65°C |
| Flash Point | 1°F |
| Appearance | Liquid |
| Color | Brown to black |
| Storage Condition | 2-8°C |
3,5-Dichlorophenylmagnesium bromide, 0.50 M in THF - Risk and Safety
| Risk Codes | R11 - Highly Flammable R14 - Reacts violently with water R19 - May form explosive peroxides R22 - Harmful if swallowed R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R12 - Extremely Flammable R37 - Irritating to the respiratory system |
| Safety Description | S16 - Keep away from sources of ignition. S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2924 3/PG 2 |
| WGK Germany | 1 |
| HS Code | 29310099 |
3,5-Dichlorophenylmagnesium bromide, 0.50 M in THF - Introduction
Bromo (3,5-dichlorophenyl)magnesium is an organic compound with the chemical formula C6H3BrCl2Mg. Its appearance is a colorless to light yellow solid, which can be dissolved in common organic solvents such as dichloromethane, ether, acetone, etc.
bromo(3,5-dichlorophenyl)magnesium is usually used in organic synthesis reactions, especially for the preparation of aromatic bromides. It can be used as a Grignard reagent (Griesard reagent) to participate in the Grignard reaction, converting halogenated aromatic hydrocarbons into Grignard reagent additives, and then preparing alcohols, aldehydes, ketones and other compounds. In addition, it can also be used in the synthesis of heterocyclic compounds, the synthesis of natural products, etc.
A common method for preparing bromo(3,5-dichlorophenyl)magnesium is by reacting magnesium and 3,5-dichlorobromobenzene (3,5-dichlorobromobenzene). The reaction is usually carried out in an inert solvent such as diethyl ether or tetrahydrofuran. Magnesium powder and 3,5-dichlorobromobenzene are added to the reaction flask, and then brominated paraffin (ethyl bromide) or ethyl bromide prepared in advance at room temperature are added dropwise. The reaction time is usually from several hours to overnight. After the reaction, the product can be extracted and purified by concentrated hydrolysis, acidic treatment, or the like.
Regarding safety, bromo(3,5-dichlorophenyl)magnesium is an organometallic compound that needs to be handled under safe operating conditions. It is irritating to the skin, eyes and respiratory system, avoid contact with skin and eyes. Appropriate protective measures such as gloves, goggles and protective clothing should be used in the laboratory. At the same time, it should be away from fire sources and strong oxidants to prevent dangerous reactions. When stored should be sealed to avoid contact with moisture.
bromo(3,5-dichlorophenyl)magnesium is usually used in organic synthesis reactions, especially for the preparation of aromatic bromides. It can be used as a Grignard reagent (Griesard reagent) to participate in the Grignard reaction, converting halogenated aromatic hydrocarbons into Grignard reagent additives, and then preparing alcohols, aldehydes, ketones and other compounds. In addition, it can also be used in the synthesis of heterocyclic compounds, the synthesis of natural products, etc.
A common method for preparing bromo(3,5-dichlorophenyl)magnesium is by reacting magnesium and 3,5-dichlorobromobenzene (3,5-dichlorobromobenzene). The reaction is usually carried out in an inert solvent such as diethyl ether or tetrahydrofuran. Magnesium powder and 3,5-dichlorobromobenzene are added to the reaction flask, and then brominated paraffin (ethyl bromide) or ethyl bromide prepared in advance at room temperature are added dropwise. The reaction time is usually from several hours to overnight. After the reaction, the product can be extracted and purified by concentrated hydrolysis, acidic treatment, or the like.
Regarding safety, bromo(3,5-dichlorophenyl)magnesium is an organometallic compound that needs to be handled under safe operating conditions. It is irritating to the skin, eyes and respiratory system, avoid contact with skin and eyes. Appropriate protective measures such as gloves, goggles and protective clothing should be used in the laboratory. At the same time, it should be away from fire sources and strong oxidants to prevent dangerous reactions. When stored should be sealed to avoid contact with moisture.
Last Update：2024-04-10 22:29:15
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